Yolk sac–embryo distance in correlation with soluble form of vascular endothelial growth factor levels in pregnancy with potentially reserved evolutivity

Carmen Elena Bucuri, Razvan Ciortea, Doru Diculescu, Andrei Malutan, Radu Mocan-Hognogi, Costin Berceanu, Renata Nicula, Maria Rada, Dan Mihu


Aims: Embryonic demise is a frequent complication of the first trimester pregnancy. The purpose of this study was to evaluate the correlation between a serum biomarker, the soluble form of the vasculo-endothelial growth factor (sFlt-1) and the distance between the yolk sac (YS) and embryo (DYSE), determined by ultrasonography.

Material and methods: The study was a prospective case-control study that included 2 groups of patients – the control group with 81 first-trimester pregnancies in evolution and the case group with 89 first-trimester pregnancies with a potentially reserved evolutivity.

Results: A correlation between the serum level of sFlt-1 and DYSE in embryos with crown-rump length (CRL) greater than 5 mm was identified, showing that a DYSE ≤3 mm correlates with a low level of sFlt-1 (p<0.05) and a DYSE> 4 mm correlates with an increased level of sFlt-1 (p<0.05).

Conclusions: A low level of sFlt-1 associated with a distance between the embryo and yolk sac of small dimensions, respectively <3 mm, correlates with an increased rate of non-viable embryos. This correlation between an ultrasound and a serum parameter is of great value and brings important information about the viability of first
trimester pregnancies.


embryonic demise; vascular endothelial growth factor; distance yolk sac–embryo

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DOI: http://dx.doi.org/10.11152/mu-1504


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