Good performance of liver stiffness measurement in the prediction of postoperative hepatic decompensation in patients with cirrhosis complicated with hepatocellular carcinoma

Bogdan Procopet, Petra Fischer, Adelina Horhat, Emil Mois, Horia Stefanescu, Mihai Comsa, Florin Graur, Adrian Bartos, Monica Lupsor-Platon, Radu Badea, Mircea Grigorescu, Marcel Tantau, Zeno Sparchez, Nadim Al Hajjar


The evaluation of patients with early hepatocellular carcinoma (HCC) referred for liver resection is still a matter of debate. 

Aims: 1) to compare liver stiffness measurement (LSM) by transient elastography with hepatic venous pressure gradient (HVPG) in the prediction of decompensation after liver resection in patients with cirrhosis and early HCC; 2) to identify which definition for posthepatectomy liver failure is better associated with survival.

Material and methods: Fifty-one patients (MELD score of 10±3) were included. In this group, 34 patients underwent HVPG measurement, of which 13 (38%) had clinically significant portal hypertension (CSPH) and 35 patients underwent LSM (21.8±17.9 kPa). The study’s end-points were: posthepatectomy liver failure (PHLF) defined according to International Study Group of Liver Surgery criteria and 3-month decompensation defined as de novo ascites, variceal bleeding, jaundice, hepatic encephalopathy and acute kidney injury. The performance of LSM compared to HVPG in predicting the end-points were assessed by AUROC curves and accuracy.

Results: Twenty (39%) patients developed PHLF and 15 (29%) developed decompensationat 3 months. Three-month decompensation tended to be better correlated with survival. LSM performed well in predicting decompensation at 3 months (AUROC=0.78, 95%CI: 0.63-0.94; p=0.01), comparable with HVPG (AUROC=0.89, 95%CI: 0.79-1.00; p<0.01) (DeLong test p=0.21). LSM was not sufficiently accurate to predict PHLF.

Conclusion: LSM has a similar performance to HVPG in predicting decompensation at 3 months in patients with early HCC submitted to liver resection. Three-month decompensation is better associated with survival.


clinical significant portal hypertension; hepatic venous pressure gradient; prognosis; liver resection; liver elastography

Full Text:




  • There are currently no refbacks.
By clicking ‘Accept’, you agree to the use of cookies, and to the Privacy Policy on this website. Read our Privacy and Cookie Policies to find out more.