The diagnostic value of washing curves obtained by dynamic contrast enhanced transvaginal ultrasonography in the diagnosis of ovarian tumors – preliminary study

Adina Stoian, Radu Badea, Razvan Ivan, Jacques Salvat


Objective: The main objective of this study was to evaluate the role of contrast-enhanced ultrasonography in the diagnosis
of ovarian masses. Methods and Materials: Seventy-three patients with morphologically abnormal ovarian masses (cystic
with focally thickened walls, with papillary excrescences or irregular solid areas, solid tumor) were investigated by contrast
enhanced transvaginal ultrasound (SonoVue). The following parameters were assessed in all ovarian masses: peak contrast
enhancement (dB), time to peak enhancement (s), half washout time and area under the enhancement curve. The histology
diagnoses were performed for all lesions included in this study. Results: Twenty-three malignant masses and fi fty benign tumors
were studied. The statistical data analysis showed a difference between benign and malignant tumors, for the following
parameters: peak contrast enhancement (mean ± SD, 4.82 ± 2.3 versus 34.09 ±7.8 dB), half washout time (23.26 ± 18 versus
41± 8.6 s) and the area under the enhancement curve (1.89± 0.7 versus 4.38± 2,5). There were no statistically signifi cant differences
for the time to peak enhancement (15 ±9.3 versus 19.17 ± 4.1). Conclusion: The quantifi cation of ultrasonographic
contrast media kinetics using pulse inversion harmonic sonography has potential to accurately differentiate between benign
and malignant ovarian tumors.


ovarian cancer; ultrasonography; contrast agent

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