Feasability, accuracy and reproducibility of transient elastography

Alexandra Deleanu, Roxana Sirli, Alina Popescu, Ioan Sporea


Background: Transient elastography (TE) is a non-invasive method for the evaluation of liver diseases which is increasingly being accepted by patients and hepatologists. Aim: To evaluate the capacity of the TE (FibroScan) in estimating liver fi brosis in clinical practice. Material and methods: During 2 years 3459 examinations were performed. The time required for examination, the rate of valid determinations and the rate of uninterpetable results, taking into account the interquartilic range
(IQR) and the success rate (SR), were evaluated. The TE reproducibility (intra- and inter-observer reproducibility analyzed
by 3 independent examiners) in 287 cases was evaluated using the intra-class correlation coeffi cient (ICC). A group of 167 healthy volunteers were examined to establish the average value of the liver stiffness. Results: The average time required for one examination was 4 min 15 s. In 94.7% of cases the determinations were valid. In 446 cases IQR was > 30% and SR <60% resulting in 13.6% of cases without TE valid results, and 86.4% TE useful results for the evaluation of the chronic liver disease. Intra-observer reproducibility for the three operators were: 0.985, 0.949, and respectively 0.874 and the inter-observe reproducibility was analyzed with overall ICC 0982. The average value of the liver stiffness in the control group was 4.8 - 1.9
kPa. Conclusions: TE is an easy and quick way to evaluate liver stiffness, user- and patient-friendly. Intra- and inter-observer reproducibility is excellent, TE being an operator-independent method.


transient elastography; fezability, accuracy; reproducibility

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