Factors that influence ultrasound evaluation of breast tumor size

Jin Xu, Ge Ma, Mengdi Liang, Yue Wang, Hong Pan, Li Li, Cuiying Li, Wenbin Zhou, Shui Wang


Aims: To determine the factors influencing ultrasound breast tumor size assessment accuracy.

Material and methods: Five factors (tumor type, molecular subtype, histological size, histological grade, and breast density) were used to assess the measurement accuracy of breast ultrasound in tumor size. Size underestimation was defined as ultrasound index lesion di-ameter < histological size by at least 5 mm.

Results: Breast ultrasound underestimated tumor size significantly, especially in cases with intraductal components (p=0.002). There was a tendency for higher size underestimation in breast cancer tumors with high–histological grade (p=0.03), human epidermal growth factor receptor type 2 (HER2)-overexpressing breast cancer tumors (p=0.02) and hormone receptor (HR)−/HER2+ breast cancer tumors (p=0.008). Furthermore, core biopsy revealed higher probability of size underestimation with intraductal components (p=0.002). Size underestimation was more frequent with larger histological size (p<0.001). Masses in non-dense breasts were significantly underestimated (p=0.036) compared to dense breasts.

Conclusions: The size underestimation was influenced by pathological type, molecular subtype, and histologi-cal size. The pathological results of core biopsy were conducive for predicting tumor size pre-surgery in precise breast cancer diagnosis.


breast cancer; ultrasound; tumor size; molecular subtype; core biopsy

Full Text:


DOI: http://dx.doi.org/10.11152/mu-1747


  • There are currently no refbacks.
By clicking ‘Accept’, you agree to the use of cookies, and to the Privacy Policy on this website. Read our Privacy and Cookie Policies to find out more.