The value of Contrast-Enhanced Ultrasound in the characterization of vascular pattern of solid pancreatic lesions

Melania Ardelean, Roxana Sirli, Ioan Sporea, Simona Bota, Mirela Danila, Alina Popescu, Bogdan Timar, Roxana Buzas, Octavian Mazilu, Ovidiu Ardelean, Daniel Lighezan


The aim of our study was to evaluate the accuracy of CEUS in the characterization of pancreatic solid lesions, considering cross sectional imaging techniques (CE-CT/MRI) as the “gold standard” methods. Material and methods: We performed a retrospective, monocentric study that included 91 solid pancreatic lesions which were evaluated by CEUS and by a second- line contrast imaging technique (CT or MRI), considered as the reference method. Results: The rate of a conclusive diagnosis based on a typical enhancement pattern was 94% (78/83 cases). In 72 cases out of 83 (86.7%) there was a perfect concordance between CEUS and the “gold-standard” imaging method (CE-CT/MRI). In our study, 88% (73/83) of the pancreatic lesions were categorized as malignant due to their typical wash-out aspect in the late phase. The overall accuracy of CEUS for the differential diagnosis of solid pancreatic tumors was approximately 81%. The accuracy of CEUS for the diagnosis of hypoen- hancing pancreatic tumors was approximately 89.1%; while for the diagnosis of hyperenhancing pancreatic tumors it was ap- proximately 72.8%. Conclusion: CEUS allows the differentiation between hypo- vs. hyperenhancing pancreatic solid lesions, with a considerable diagnostic accuracy, a fundamental step in the precise diagnosis of pancreatic tumors.


cross sectional imaging techniques; enhancement pattern; pancreatic tumors; CEUS

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